We know what you're doing ... the website that exposes your ill-advised Facebook statuses.
Hate your boss? Hungover after a big night? Don?t head to Facebook to vent your feelings.
A new website created by a British teenager highlights the dangers of revealing private information on social networking services.
We Know What You?re Doing exposes the compromising status updates of Facebook and Foursquare users who haven?t set their accounts to private.
?I?m getting so mad right now I hate my boss Jay I hope he dies better yet I feel like killin him,? says Anastasia R, while Thomas L announces that it ?feels great to be not hungover for first Friday in ages?.
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WKWYD?s search tool scours Facebook and Foursquare for key words such as "hungover" and ?cannabis? and divides the findings into four categories: ?Who wants to get fired??, ?Who?s hungover??, ?Who?s taking drugs?? and ?Who?s got a new phone number??.
The so-called ?social networking privacy experiment? is the brainchild of 18-year-old web developer Callum Haywood. The British teenager's creation is proving incredibly popular. According to Haywood, the site has received over 400,000 visitors since its launch on Monday.
?I created the website to make people aware of the issues that are created when they post such information on Facebook without any privacy settings enabled,? Haywood told CNN. ?The people featured on the site are most likely not aware that what they post as ?public? can be seen by absolutely anybody, and that Facebook will happily give away this information to other websites via its Graph API.?
While those featured on WKWYD may be surprised to find themselves on the site, the web developer hasn?t used any published information that users haven?t already revealed publicly.
In a post on its website, computer security site Sophos claims that there?s ?nothing slimy or hackerish? about Haywood?s experiment.
Sophos also argues that the responsibility for potentially damaging status updates lies not with Facebook, but with users. ?At the very least, people have got to start paying attention to Facebook's privacy settings.?
Social media expert Jenna Price agrees. ?You need to be really careful of your online presence because it?s your reputation,? says the University of Technology Sydney academic. ?When you go online and trash your reputation, and you do it yourself, you?ve only got yourself to blame.?
According to Price, the public have been given countless warnings about the dangers of failing to protect their privacy online, but many have failed to heed the warnings. To Price, WKWYD? is using humour to deliver an important message. ?I think if it draws attention to complete abject stupidity that?s a good thing.?
WKWYD is not the first site to highlight the risks of oversharing online. Please Rob Me collated public check-ins from social networking services to announce when users would be away from home. Another social media aggregator, Openbook, makes it possible to search public Facebook status updates in real time.
By contrast to Please Rob Me and Openbook, WKWYD is careful not to reveal too many details about the people it features. Haywood only lists users by their first name and doesn?t link to their profiles.
There was some good news today for those who have been caught out by WKWYD. Haywood took to Twitter to announce that he will introduce a new feature tomorrow which will allow anyone featured on the site to request the removal of their post.
To avoid having your private thoughts exposed on WKWYD, Haywood recommends that users head to Facebook?s privacy setting ?and make sure Control Your default Privacy is not set to ?Public??.
Making the shortest light bursts leads to better understanding of naturePublic release date: 29-Jun-2012 [ | E-mail | Share ]
Contact: Charles E. Blue cblue@aip.org 301-209-3091 American Institute of Physics
An attosecond is a ridiculously brief sliver of time a scant billionth of a billionth of a second. This may seem too short to have any practical applications, but at the atomic level, where electrons zip and jump about, these vanishingly short timescales are crucial to a deeper understanding of science.
In a paper accepted for publication in the American Institute of Physics' journal Review of Scientific Instruments, a team of researchers describes an advanced experimental system that can generate attosecond bursts of extreme ultraviolet light. Such pulses are the shortest controllable light pulses available to science. With these pulses, according to the researchers, it's possible to measure the dynamics of electrons in matter in real-time. Advances in attosecond science may enable scientists to verify theories that describe how matter behaves at a fundamental level, how certain important chemical reactions such as photosynthesis work. Additional advances may eventually lead to the control of chemical reactions.
"Understanding how matter works at the level of its electrons is likely to lead to new scientific tools and to novel technologies," said Felix Frank, of Imperial College in London and one of the authors on the paper. "In the future, this knowledge could help us to make better drugs, more efficient solar cells, and other things we can't yet foresee."
The researchers were able to produce these pulses by a process called high harmonic generation (HHG). The fundamental technology driving their setup is a high-power femtosecond laser system (femtoseconds are three orders of magnitude longer than attoseconds). The near infrared femtosecond laser pulses are corralled through a waveguide and a series of specialized mirrors, causing them to be compressed in time. With their waveforms precisely controlled, these compressed pulses are then focused into a gas target, creating an attosecond burst of extreme ultraviolet radiation. The experimental system developed by the researchers is able to accurately measure the attosecond pulses and deliver them to a variety of experiments in conjugation with other precisely synchronized laser pulses. "Though it incorporates many novel features, our system builds on a decade of research conducted by physics groups around the world," said John Tisch, lead scientist developing the technology at Imperial College.
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Making the shortest light bursts leads to better understanding of naturePublic release date: 29-Jun-2012 [ | E-mail | Share ]
Contact: Charles E. Blue cblue@aip.org 301-209-3091 American Institute of Physics
An attosecond is a ridiculously brief sliver of time a scant billionth of a billionth of a second. This may seem too short to have any practical applications, but at the atomic level, where electrons zip and jump about, these vanishingly short timescales are crucial to a deeper understanding of science.
In a paper accepted for publication in the American Institute of Physics' journal Review of Scientific Instruments, a team of researchers describes an advanced experimental system that can generate attosecond bursts of extreme ultraviolet light. Such pulses are the shortest controllable light pulses available to science. With these pulses, according to the researchers, it's possible to measure the dynamics of electrons in matter in real-time. Advances in attosecond science may enable scientists to verify theories that describe how matter behaves at a fundamental level, how certain important chemical reactions such as photosynthesis work. Additional advances may eventually lead to the control of chemical reactions.
"Understanding how matter works at the level of its electrons is likely to lead to new scientific tools and to novel technologies," said Felix Frank, of Imperial College in London and one of the authors on the paper. "In the future, this knowledge could help us to make better drugs, more efficient solar cells, and other things we can't yet foresee."
The researchers were able to produce these pulses by a process called high harmonic generation (HHG). The fundamental technology driving their setup is a high-power femtosecond laser system (femtoseconds are three orders of magnitude longer than attoseconds). The near infrared femtosecond laser pulses are corralled through a waveguide and a series of specialized mirrors, causing them to be compressed in time. With their waveforms precisely controlled, these compressed pulses are then focused into a gas target, creating an attosecond burst of extreme ultraviolet radiation. The experimental system developed by the researchers is able to accurately measure the attosecond pulses and deliver them to a variety of experiments in conjugation with other precisely synchronized laser pulses. "Though it incorporates many novel features, our system builds on a decade of research conducted by physics groups around the world," said John Tisch, lead scientist developing the technology at Imperial College.
###
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?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
1. Your in-game name: Tcg10737
2. Server that you were banned on: Originally PERP and then today on all other server
3. The Banning admin: Originally Darkwing Duck, then Kigen
4. Your Steam-Id: STEAM_0:0:41725162
5. Reason for ban: On perp it was for RDM + Random mollies and I deserved that and was going to wait a while until making an unban request for PERP and just play on other HG servers. After the PERP ban I got very much into Minigames and Gungame and have been playing on there for 2 weeks with no problems at all and I am now ranked 3rd in Minigames. Im not here to contest the ban on PERP even though I would love to be unbanned on there I know I deserved the ban but what i would like to unbanned on the other HG servers.
Last edited by Mark; Yesterday at 10:50 PM.
Bans are global to all servers. You can't be banned from one without being banned from all the others. Darkwing Duck originally banned you so this falls on him to decide.
But I was since the 19th. When I was banned on PERP it said "You are Permanently banned from HellsGammers" but I could get on every other server. But I'll wait for DarkWing either way.
Tcg, although I haven spoken with you in teamspeak many times and you are a respectful, and most of the time a mature person. I think it would be beneficial for you to take a little more time away from our servers. You have had many chances with regards to the rules in perp, and I have personally spoken to you directly about rule breaking twice. Post an unban request in another month from now.
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In today?s world of Internet, E-commerce is becoming a highly developed business. Everyone who is now online business dealer needs a website as well as payment gateways. Payment gateways are almost a necessity for online stores that allow credit card/ debit card payment. A Payment Gateway Development is an essential component of any online business to take things forward.
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Payment Processing Systems automatically process the payment transaction between the shopper and merchant. It is usually a third-party service that is actually a system of computer processes that process, verify, and accept or decline credit card transactions on behalf of the merchant through secure Internet connections. Payment engine is a software application designed to manage the processing of a transaction from card swipe to authorization.
Just Hire Payment Gateways Developers For A Successful Business
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1. Manual Payment Gateway: This type of payment gateway takes the customers' credit card details and stores them for you to access and process manually through a facility such as an eftpos machine which are inexpensive but they require manual processing for each payment.
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3. Real time payment gateway: This is also very professional and an efficient gateway solution. In this, payments are processed at the point of the sale on your website
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There is a cynical view of American voters that they don't care about the truth -- that they can be bamboozled into being persuaded by negative ads. "Negative ads work," is the trite expression that gets an almost unanimous nod of the head, even among those who hate them.
Well, that might be true if candidates accept the conventional wisdom from their top strategists to ignore the ads ("don't dignify them -- stay on message," was the advice reportedly given to Democratic presidential nominee John Kerry in 2004 about the "Swift Boat" ads.)
Since most candidates follow this advice, it's hard to find examples to prove that it is the wrong counsel and that negative ads, when successfully challenged as false or misleading, can be made to backfire. But I have one very good one.
In 2005, then-Virginia Lt. Gov. Timothy Kaine (now running for the U.S. Senate) was subjected to a series of attacks by his Republican opponent in their race for the Virginia governorship.
Beginning in early October, then-Virginia Attorney General Jerry Kilgore, consistently ahead in the polls, focused most of his TV ad spending on attacking Kaine for his opposition to the death penalty, which was favored by Virginia voters by more than 2 to 1. Kaine explained that his opposition was based on religious conviction, but that as governor he would follow the law and would exercise his clemency powers sparingly.
Nevertheless, Kilgore deluged the TV airwaves with ads, stating that Kaine had said not even Adolf Hitler deserved the death penalty. But Kaine immediately published a full transcript of the interview from which the reference to Hitler was derived, and the transcript said just the opposite -- that Hitler "deserve[d] the death penalty." Then Kaine took to the airwaves with his own ads, making Kilgore's lies the issue.
The polls turned in Kaine's favor. Editorials and newspaper stories ran throughout the state highlighting the dishonesty of Kilgore and the ads he sponsored and condoned.
The Roanoke Times wrote on Oct. 13, 2005, in an editorial, "Kilgore drags the governor's race to an insulting new low with his attack on Tim Kaine's principled stance on the death penalty."
So when Tim Kaine came from behind and won on Election Day by a substantial margin of 6 percentage points -- 52 percent to 46 -- he did more than win the governorship of Virginia. He won the battle for truth -- and the vindication of the fact that voters are not stupid and don't like someone who thinks that they can be fooled by lies.
Last November, Mitt Romney was caught when his campaign ran an ad that showed Barack Obama stating that he knew little about economic issues. But it turned out that statement was actually referring to Sen. John McCain's (R-Ariz.) own admission, not Obama's. Romney was unapologetic about the lie: "What's sauce for the goose is sauce for the gander," he said.
On April 30, Glenn Kessler wrote in his must-read Washington Post "Fact Checker" series that an ad produced by a pro-Romney super-PAC falsely accused President Obama of sending "billions" of stimulus dollars overseas to pay for green jobs. Kessler pointed out that these assertions were debunked two years ago by PolitiFact and Factcheck.org. "Yet here the erroneous assertions emerge yet again, without any shame, labeled as 'the truth' or 'fact,' " Kessler wrote. These ads were awarded the ultimate "liars" grade of "Four Pinocchios."
Unfortunately, the Obama campaign is not yet in a position to do what Tim Kaine did -- i.e., to use these lies against Romney and to prove that negative ads can backfire.
Last week, Kessler documented another false and misleading Obama campaign ad, this one about Romney's alleged record at Bain and as governor of Massachusetts supporting the outsourcing of jobs to foreign countries. Kessler wrote,
"On just about every level, this [Obama campaign] ad is misleading, unfair and untrue, from the use of 'corporate raider' to its examples of alleged outsourcing. Simply repeating the same debunked claims won't make them any more correct."
Ultimately, Kessler gave the Obama campaign the same grade of "Four Pinocchios."
Nothing for any Democrat, much less the president, to be proud of.
So once again I ask President Obama's campaign about its tactical judgment here:
When you have the facts and the issues on your side, why stretch the truth at all, much less intentionally state demonstrable falsehoods? Why not win the campaign on the issues -- and on President Obama's positions on the issues and his vision for creating jobs and economic recovery, which, in my view, are far superior to Romney's?
To the president I say: Yes, you can.
# # # #
Davis, the principal in the Washington law firm of Lanny J. Davis & Associates, which also specializes in legal crisis management, served as President Clinton's special counsel from 1996-98 and as a member of President George W. Bush's Privacy and Civil Liberties Oversight Board (2006-07). He currently serves as Special Counsel to Dilworth Paxson. He is the author of the book "Scandal: How 'Gotcha' Politics Is Destroying America" and the forthcoming book, "Crisis Tales - Five Rules for Handling Scandal in Business, Politics and Life," to be published by Simon & Schuster.
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Follow Lanny Davis on Twitter: www.twitter.com/@lannydavis
Planning elder care is fraught with emotional minefields. Perhaps nothing is harder than when dementia or Alzheimer?s strike, and a loved one?s skills or judgment has degraded and family action is required. This may mean taking away car keys, insisting that a caregiver comes part of the week, or that the elder move to live in a facility. ?This is always easier if you know that your parent, when entirely competent, had expressed a preference for how to handle the situation. The trouble is that we find that many families have not made such plans.
This is a lesson learned on navigating that difficult terrain.?For today, we will assume the elder is competent to make decisions.? This leads to our first recommendation:
1.??????Start the conversation before action is required.? This conversation is rarely easy, but the more hypothetical it is, the easier for all of us to deal with the approach of mortality ? our own and that of people we love.? Even then some people resist ? ?That?s not going to happen to me. I?m going to die of a stroke like my dad? or ?If that happens, we?ll have to deal with it at the time? might be common dodges.? But however difficult the conversation, it will not get easier by waiting until the elder?s abilities have declined. ?Start early, and sensitively. 2.??????Keeping it hypothetical is often easier.??Dad, we all hope you live to 100 and die in your sleep. But if that didn?t happen, what would you like us to do if we realized you weren?t able to drive safely??? ?Mom, this is still a long way off, but if you got like Aunt Edith and couldn?t make good decisions any more, would you prefer to have care at home, or to move to a place where people could be sure you had everything you need?? Even if you?re sure Dad won?t make it that long, or you suspect a Mom?s judgment may have already begun to falter, you do not need to make an issue of that now. For today, the goal is to understand clearly how someone would want decisions made if he or she were not able to make them. A hypothetical discussion may reduce resistance. 3.??????Clarify that you are not trying to rush decisions.?Your goal in raising this point is to handle a situation that may not even be required in the future. Be sure your loved one knows this is not a smoke screen to fool them into agreeing to something against their will. 4.??????Emphasize that you want to help the person have what he or she wants.Resistance is often strongest when people are afraid they are losing control. The more you can reassure your loved one that the point of this conversation is to maximize the chances that decisions are made the way he or she prefers, the more likely you will be able to have a productive conversation. 5.??????Remember that the goal is to understand you loved one?s desires.?This is not the time to bring up changes you want to make. In this discussion, you are focused on learning from your loved one what he or she wants.? Answers should sound like, ?Even if I have dementia, I want to stay at home as long as possible so I can be in my garden. That makes me happy.?? Or, ?If you suspected I could not drive safely, then I would want to be evaluated by Dr X because Betty would have taken away my keys 10 years ago if she could.? 6.??????Respond sensitively to resistance.?Remember that your loved one likely suspects that this day approaches far more rapidly than he or she wishes. Denial may be the only protection they know from fear and great sadness. Unreasonableness is often frustrating, and you may need a lot of patience to conduct this discussion. It may take several different discussions and you may have to find a way to return to the topic without nagging. 7.??????Ask for help.?Often a family friend, clergyperson, or counselor can help start a conversation that is more difficult within the family. Do not hesitate to ask, if it will help move the discussion along.?
Families often delay these conversations too long.? ?Delay is a natural, although very risky, response. We find that families who have had these discussions in advance, and know in their hearts that they are doing what mom and dad said they would want, are more at peace and are better able to make difficult decisions if and when the time comes.
Jim Reynolds is the CEO of Caring Companion Home Care in Concord, MA.?
WOODBRIDGE, N.J. -- If Mitt Romney gets elected president, you can be sure this promise of his will be revisited.
The former Massachusetts governor and presumptive Republican nominee told supporters here at a Tuesday evening fundraiser that under President Romney, the U.S. economy will make a dramatic turnaround.
"If I become president, you're going to see an economic resurgence: manufacturing resurgence, high-tech, health care. You're going to see this economy take off," Romney said. "And I say that because I know what I'm going to do, and I know what kind of impact it will have."
President Barack Obama's campaign has made one of its core thrusts of late to charge that Romney has not revealed details of what he would do if elected on topics that include closing tax loopholes, upholding or repealing Obama's recent quasi-executive order halting deportation of undocumented immigrant children.
But Romney campaign spokeswoman Andrea Saul responded to those critics in an email Tuesday.
"The focus of this campaign is getting the economy back on track and we?ve released a 160-page guide for how Gov. Romney would do just that," Saul wrote. "We are still waiting for a single plan or new idea from President Obama that would help the economy."
Romney, at a fundraiser attended by more than 200 supporters in a hotel ballroom (contributors gave $2,500 for admission, $10,000 for a photo with Romney, $25,000 for a VIP reception, and $50,000 for a private dinner), continued to hammer Obama for focusing on health care early in his presidency instead of on turning the economy around.
"This is a tough time, and it didn't have to be this way," Romney said.
He said that if Obama had followed "the first three rules of any enterprise in trouble, whether government, a charity, a family, anything," he could have avoided such a prolonged economic downturn and slow recovery.
"There are three rules that we used to follow in my prior business career, in a turnaround: focus, focus and focus. Focus on the most important thing with all of your energy and passion. And this president came into office and there was one issue that was on everyone's mind: the economy," Romney said. "He turned and focused on entirely different things."
Earlier in the day, the Republican National Committee sent out a memo detailing passages from a recent book on the president's first term that described Obama as setting the economy on the back burner and choosing to pursue a more historic accomplishment than economic stabilization.
It is GOP's the prelude to the Supreme Court's ruling that is expected to be delivered on Thursday morning on Obama's health care law. Romney hit the same theme as the RNC memo.
"They focused on Obamacare, spent two, three years fighting to put in place their idea of a liberal vision for health care. And now the Supreme Court's about to take a look at it. If the Supreme Court lets it stand, well it will make it very clear to the American people they must elect someone who will stop it," Romney said. "If they overturn it, and they say it's unconstitutional as I believe it is, then the first 3.5 years of the Obama administration have been entirely wasted."
Romney also took a shot at Obama for the president's joke to supporters in Massachusetts on Monday about the Boston Red Sox trade of player Kevin Youkilis to the president's hometown team, the Chicago White Sox, which drew some boos from the crowd.
"You saw that President Obama came up to Massachusetts, shows he doesn't really understand the audience terribly well," Romney said. "He went up there and criticized the Boston Red Sox. You know, you don't talk about Kevin Youkilis in a negative tone or you might get yourself booed by your own constituency."
White House press secretary Jay Carney protested to reporters on Tuesday, aboard Air Force One, that most of the boos from the audience were actually chants of Youkilis' name.
"Anyone who knows Boston and knows the Red Sox, and who was in that room, knows that the preponderance of people shouting in response to what the president said about Kevin Youkilis were saying 'Youk,' not 'Booo' for God?s sake," Carney said.
Romney was introduced at the fundraiser by New Jersey Gov. Chris Christie, who said Obama has "made America a more pessimistic place" and mocked the president's campaign slogan.
"He doesn't have a coherent message about America's future. All he says on the little sign on the front of his podium is, 'Forward,'" Christie said. "No, what this is is backward."
Christie, considered to be a possible vice presidential pick for Romney, said he is "ready to do whatever he needs me to do to make sure that on January 20 of 2013 a new day starts for America."
Romney joked with the crowd that he was "hoping somebody in here would start to heckle [Christie], so I could watch him go to town.
"Yeah, but you know better don't ya?" Romney joked, to much laughter.
Christie's brother, Todd, made brief remarks earlier, and said the fundraiser was going to "go way over" the $1.6 million that New Jersey Republicans raised for Romney at a December fundraiser. The Romney campaign did not disclose how much it planned to raise Tuesday night.
SAN FRANCISCO?? A judge late Tuesday ordered Samsung Electronics Co. to halt sales of its Galaxy 10.1 tablet computer while the court considers Apple's claim the South Korean tech giant illegally copied the design of the popular iPad.
U.S. District Judge Lucy Koh said Apple Inc.'s lawsuit appeared likely to prevail.
"Apple has established a strong case on the merits," Koh said.
Koh had earlier said the two products are "virtually indistinguishable," but she declined in December to take the dramatic step of prohibiting sales of the Galaxy 10.1. She changed her mind after the U.S. Court of Appeals for the Federal Circuit told Koh to take another look at Apple's request for an injunction, ruling June 19 that it appeared the Cupertino-based company had a strong case. The Washington, D.C., court handles most patent appeals.
"Although Samsung has a right to compete, it does not have a right to compete unfairly, by flooding the market with infringing products," Koh wrote in her Tuesday order. She said Apple would be "irreparably harmed" if sales of the Galaxy 10.1 continued.
Samsung said it was disappointed with the court's decision.
"We will take necessary legal steps and do not expect the ruling to have a significant impact on our business operations, as we possess a diverse range of Galaxy Tab products," it said in a statement.
Koh ordered Apple to post a $2.6 million bond in case it ultimately loses the case.
The ruling is a small part of a much larger patent battle between the two tech giants, who are scheduled to go to trial next month in San Jose.
Apple filed its lawsuit last year, and the two companies are enmeshed in patent disputes around the globe revolving around smartphones and handheld computers. Samsung, with its Android-powered products, has emerged as one of Apple's chief rivals.
Apple also accuses the South Korean company of infringing patents related to the iPhone. Apple is seeking a similar injunction barring Samsung from selling one of its smartphones in the United States.
Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
Parkinson's disease gene identified with help of Mennonite family: UBC-VCH researchPublic release date: 27-Jun-2012 [ | E-mail | Share ]
Contact: Brian Lin brian.lin@ubc.ca 604-822-2234 University of British Columbia
An international team led by human genetic researchers at the University of British Columbia and Vancouver Coastal Health has identified the latest gene associated with typical late-onset Lewy body Parkinson's disease (PD), with the help of a Canadian Mennonite family of Dutch-German-Russian ancestry.
Twelve of the 57 members of the Saskatchewan family who participated in the study had previously been diagnosed with PD.
UBC Medical Genetics Prof. Matthew Farrer, who led the research, notes that unequivocal confirmation of the gene's linkage with PD required DNA samples from thousands of patients with PD and healthy individuals. He refers to the new discovery as the "missing link," as it helps to unify past genetic discoveries in PD.
"A breakthrough like this would not be possible without the involvement and support of the Saskatchewan Mennonite family who gave up considerable time, contributed clinical information, donated blood samples, participated in PET imaging studies and, on more than one occasion following the death of an individual, donated brain samples," says Farrer, Canada Excellence Research Chair in Neurogenetics and Translational Neuroscience and the Dr. Donald Rix BC Leadership Chair in Genetic Medicine.
"We are forever indebted to their generosity and contribution to better understanding and ultimately finding a cure for this debilitating disease."
The mutation, in a gene called DNAJC13, was discovered using massively parallel DNA sequencing. Conclusive evidence came from the identification of the gene mutation in several other families across many Canadian provinces, including British Columbia.
"This discovery is not only significant for researchers, but also for those families carrying this genetic mutation and afflicted with this disease in that it offers hope that something good might yet result from their suffering," says Bruce Guenther, President of the Mennonite Brethren Biblical Seminary Canada, a community leader and spokesperson for the family that participated in the study.
"The family involved is very grateful for the research team's respectful, collaborative and sensitive approach, and we hope that this enables the discovery of more effective treatments, and hopefully eventually a cure."
The discovery resulted from a longstanding collaboration with neurology colleagues, Ali and Alex Rajput at the University of Saskatchewan and Silke Cresswell and Jon Stoessl at UBC. The research team also includes scientists from McGill University, the Mayo Clinic in Florida, and St. Olav's Hospital in Norway.
Farrer shared the discovery last week with the medical community as part of his keynote speech in Dublin today at the 16th International Congress of Parkinson's Disease and Movement Disorders (Plenary Session V: Is it time to change how we define Parkinson's disease?) Details of the study was presented at the conference and is being submitted for publication.
"The identification of DNAJC13 will certainly be of interest to people around the world who trace their family history to the nineteenth-century Mennonite colonies in Russia, and who have family members suffering from Parkinson's disease," Guenther adds.
BACKGROUND | New Parkinson's gene identified
Parkinson's disease (PD) is the second most common chronic neurodegenerative disorder after Alzheimer's. According to the U.S. National Institutes of Health, Parkinson's disease affects more than one million people in North America and more than four million people worldwide.
The late-onset form is the most common type of PD. The risk of developing late-onset PD increases with age but most patients begin showing symptoms in their late 60s and early 70s.
Once considered a sporadic disease, latest studies have shown genetic components of PD that provide the foundation for neuroscience research and potential treatment targets.
Approximately 15 per cent of people with PD have a family history of the disorder. There is a higher rate of PD in families where two or more members are affected, possibly due to a shared genetic susceptibility among blood relatives.
UBC Prof. Matthew Farrer is an internationally renowned expert in the genetic aspects of PD and related dementia. He and his team have helped identified many genes involved in PD by analyzing DNA from families throughout the world.
Farrer and his research team are based at the Department of Medical Genetics at UBC's Faculty of Medicine, and at the Brain Research Centre at UBC and Vancouver Coastal Health Research Institute. He has had an adjunct Faculty in Medicine (Neurology) at the University of Saskatchewan since 2003.
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For more information on the genetic aspects of PD, visit http://www.can.ubc.ca/parkinson-disease/genetics/.
Answers to frequently asked questions about genetic testing are available at http://www.can.ubc.ca/parkinson-disease/genetics/genetic-testing-faq/.
Photos of Prof. Matthew Farrer are available at http://www.publicaffairs.ubc.ca/?p=51691.
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Parkinson's disease gene identified with help of Mennonite family: UBC-VCH researchPublic release date: 27-Jun-2012 [ | E-mail | Share ]
Contact: Brian Lin brian.lin@ubc.ca 604-822-2234 University of British Columbia
An international team led by human genetic researchers at the University of British Columbia and Vancouver Coastal Health has identified the latest gene associated with typical late-onset Lewy body Parkinson's disease (PD), with the help of a Canadian Mennonite family of Dutch-German-Russian ancestry.
Twelve of the 57 members of the Saskatchewan family who participated in the study had previously been diagnosed with PD.
UBC Medical Genetics Prof. Matthew Farrer, who led the research, notes that unequivocal confirmation of the gene's linkage with PD required DNA samples from thousands of patients with PD and healthy individuals. He refers to the new discovery as the "missing link," as it helps to unify past genetic discoveries in PD.
"A breakthrough like this would not be possible without the involvement and support of the Saskatchewan Mennonite family who gave up considerable time, contributed clinical information, donated blood samples, participated in PET imaging studies and, on more than one occasion following the death of an individual, donated brain samples," says Farrer, Canada Excellence Research Chair in Neurogenetics and Translational Neuroscience and the Dr. Donald Rix BC Leadership Chair in Genetic Medicine.
"We are forever indebted to their generosity and contribution to better understanding and ultimately finding a cure for this debilitating disease."
The mutation, in a gene called DNAJC13, was discovered using massively parallel DNA sequencing. Conclusive evidence came from the identification of the gene mutation in several other families across many Canadian provinces, including British Columbia.
"This discovery is not only significant for researchers, but also for those families carrying this genetic mutation and afflicted with this disease in that it offers hope that something good might yet result from their suffering," says Bruce Guenther, President of the Mennonite Brethren Biblical Seminary Canada, a community leader and spokesperson for the family that participated in the study.
"The family involved is very grateful for the research team's respectful, collaborative and sensitive approach, and we hope that this enables the discovery of more effective treatments, and hopefully eventually a cure."
The discovery resulted from a longstanding collaboration with neurology colleagues, Ali and Alex Rajput at the University of Saskatchewan and Silke Cresswell and Jon Stoessl at UBC. The research team also includes scientists from McGill University, the Mayo Clinic in Florida, and St. Olav's Hospital in Norway.
Farrer shared the discovery last week with the medical community as part of his keynote speech in Dublin today at the 16th International Congress of Parkinson's Disease and Movement Disorders (Plenary Session V: Is it time to change how we define Parkinson's disease?) Details of the study was presented at the conference and is being submitted for publication.
"The identification of DNAJC13 will certainly be of interest to people around the world who trace their family history to the nineteenth-century Mennonite colonies in Russia, and who have family members suffering from Parkinson's disease," Guenther adds.
BACKGROUND | New Parkinson's gene identified
Parkinson's disease (PD) is the second most common chronic neurodegenerative disorder after Alzheimer's. According to the U.S. National Institutes of Health, Parkinson's disease affects more than one million people in North America and more than four million people worldwide.
The late-onset form is the most common type of PD. The risk of developing late-onset PD increases with age but most patients begin showing symptoms in their late 60s and early 70s.
Once considered a sporadic disease, latest studies have shown genetic components of PD that provide the foundation for neuroscience research and potential treatment targets.
Approximately 15 per cent of people with PD have a family history of the disorder. There is a higher rate of PD in families where two or more members are affected, possibly due to a shared genetic susceptibility among blood relatives.
UBC Prof. Matthew Farrer is an internationally renowned expert in the genetic aspects of PD and related dementia. He and his team have helped identified many genes involved in PD by analyzing DNA from families throughout the world.
Farrer and his research team are based at the Department of Medical Genetics at UBC's Faculty of Medicine, and at the Brain Research Centre at UBC and Vancouver Coastal Health Research Institute. He has had an adjunct Faculty in Medicine (Neurology) at the University of Saskatchewan since 2003.
###
For more information on the genetic aspects of PD, visit http://www.can.ubc.ca/parkinson-disease/genetics/.
Answers to frequently asked questions about genetic testing are available at http://www.can.ubc.ca/parkinson-disease/genetics/genetic-testing-faq/.
Photos of Prof. Matthew Farrer are available at http://www.publicaffairs.ubc.ca/?p=51691.
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Garmin is adding a new product to its line-up of fitness watches, and this one is dedicated to workouts of the aquatic variety. The Garmin Swim tracks your distance swam, average pace, workout time and more, and it uploads those stats to the web to help monitor your progress. Though it's meant to be a part of your exercise routine, the Garmin Swim watch looks like your average plastic digi-timepiece. The watch has six buttons with functions for viewing the time of day, scrolling through the menu options, controlling the timer, viewing the menu and entering workout mode. The setup takes some getting used to, but the illustrative icons on the watch helped us get into the rhythm quickly.
Getting started with the Swim simply entails entering the size of your pool, with options to measure in yards or meters. Once that info is uploaded, you press the swim button and are ready to get splashing. We spent a solid half-hour doing laps, and the Swim duly recognized and recorded that we varied our strokes. Stopping the timer each time we took a break created a new interval for our workout, with a rundown of the elapsed time, distance in meters, number of strokes, type of stroke, total laps, average speed and calories burned. That's a lot of data to pore over, and Garmin lets you wirelessly upload it all to the Garmin Connect site. To do this, you have to pair the watch with your computer using a USB ANT stick: once it works, it's an efficient, easy way to review your workout, but it took us a few tries before our laptop recognized the watch. Garmin says the watch's battery will last a full year, which is plenty of time to log some serious laps. For more about the Swim, check out the press info past the break.
ScienceDaily (June 26, 2012) ? A new study published June 26 in the Journal of the American Medical Association (JAMA) found that the federal government made about $13 billion in duplicative payments to provide health-care services to veterans who were simultaneously enrolled in Medicare Advantage plans from 2004-2009.
The study was conducted by researchers at Brown University, VA Palo Alto Medical Center and the Institute for Population Health Improvement at UC Davis Health System.
Some veterans are entitled to health-care coverage through both the U.S. Department of Veterans Affairs Health Care System and Medicare. But under current law, the federal government often ends up paying twice for care of veterans when they are also enrolled in Medicare Advantage managed-care plans. And with the growing popularity of Medicare Advantage plans among all seniors, including veterans, the annual duplicative costs are rising. Nearly 30 percent of Medicare beneficiaries are now enrolled in Medicare Advantage plans.
"These 'dual eligible' veterans earned the right to receive care through both VA and Medicare, but that does not mean that the government has to pay twice for their care," said Kenneth W. Kizer, a former VA Under Secretary for Health and now a professor and director of the Institute for Population Health Improvement at the University of California, Davis, Health System. "The problem could be fixed without reducing benefits to veterans.
"Duplicative costs occur because of way the federal government pays for Medicare Advantage services for veterans, not because veterans are receiving unnecessary care or doing anything wrong," he added.
Veterans who are disabled or over age 65 and have been paying into the Medicare program are eligible for Medicare just like any other American. Veterans who live far from a VA hospital or clinic may especially rely on Medicare coverage for acute or emergency care. But unlike the traditional Medicare fee-for-service program, Medicare Advantage plans are paid in advance to provide all needed care for the beneficiary. If the person enrolled in the Medicare Advantage plan then gets his or her medical care in another federal health plan such as the VA, it means that the federal government has paid twice for care of the same person. Most of the Medicare Advantage plans are for-profit health plans.
To assess duplicative costs, the researchers conducted a comprehensive review of VA and Medicare records for more than 1 million veterans over a 6-year period. The researchers found that 61 percent of doubly-covered veterans used both VA and Medicare Advantage coverage, with 10 percent of dual-eligible veterans receiving all their health care from the VA. That is, 10 percent of these dual eligible veterans received all their health care from the VA despite Medicare paying the Medicare Advantage plan to provide those services. About 4 percent of the dual-eligible veterans sought no care from Medicare Advantage or the VA, and 35 percent used Medicare only.
The number of veterans doubly covered by Medicare Advantage and the VA has risen nearly 53 percent in recent years, from 485,651 in 2004 to 924,792 in 2009. The yearly federal spending in the VA for these dual-eligible veterans rose from $1.3 billion in 2004 to $3.2 billion in 2009. The costs to take care of Medicare Advantage beneficiaries now amounts to 10 percent of the VA's budget for medical care.
But Kizer believes the government can eliminate the duplicative spending without reducing care for veterans by changing the way that Medicare Advantage payment rates are calculated or by changing the law so that the VA could bill Medicare Advantage plans for care that it provides to veterans, as is currently the case with private insurance plans. While the VA may bill private insurers, the law does not allow VA to bill Medicare or Medicare Advantage plans.
"In light of the severe financial pressure facing the Medicare program, policymakers should take steps to identify and eliminate redundant expenditures such as found in this study," Kizer said.
In addition to Kizer, the study's other authors include Amal Trivedi, Regina Grebla, Lan Jiang and Vincent Mor at the Providence VA Medical Center and Jean Yoon at the VA Palo Alto Medical Center.
The research was supported by the U.S. Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Health Services Research and Development Service, and the National Institute of Aging (5RC1AG036158).
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The above story is reprinted from materials provided by University of California - Davis Health System.
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Journal Reference:
Regina C. Grebla. Duplicate Federal Payments for Dual Enrollees in Medicare Advantage Plans and the Veterans Affairs Health Care SystemDuplicate Federal Payments for Dual Enrollees. JAMA: The Journal of the American Medical Association, 2012; : 1 DOI: 10.1001/jama.2012.7115
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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
The?Smartphone & Tablet Games Summit is set to take place tomorrow in San Francisco! Join the industry?s leading mobile gaming developers, investors and executives for panels, discussions and networking. Sessions will revolve around successful game design, development, distribution and monetization.?Register before midnight for only $499, a $200 savings.
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New Career Opportunities Daily: The best jobs in media.
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It would be wonderful to see something sweet incorporated into the logo (Candy) and/or a curvy illustration of a bigger woman. It could be just a silhouette or pin-up girl image but larger then average in size that you see from those images from the 50s. Anything girly on the logo is also fine - flowers, hearts, butterfly, full lips ...etc.
My focus is on selling dresses, lingerie, club wear and costumes.
Insight into quantities maxes out in adulthood and may influence math achievement
Web edition : 3:03 pm
Even 6-month-old babies can rapidly estimate approximate numbers of items without counting. But surprisingly, an apparently inborn sense for numbers doesn?t top out until around age 30.
Number sense precision gradually declines after that, generally falling to preteen levels by about age 70, say psychologist Justin Halberda of Johns Hopkins University in Baltimore and his colleagues. They report the findings, based on Internet testing of more than 10,000 volunteers ages 11 to 85, online the week of June 25 in the Proceedings of the National Academy of Sciences.
?I expected to see some improvement in number sense into preschool or maybe early elementary school, but not up to age 30,? Halberda says.
Evidence of critical mental abilities peaking after young adulthood is rare but has been reported for face memory (SN: 1/1/11, p. 16).
Participants in the new study completed a game that tested the precision of their number sense, or how accurately they could assess quantities. Volunteers saw a series of images showing mixes of blue and yellow dots and judged which color dot was more numerous. Each dot array appeared for a fraction of a second.
In some dot arrays, one color greatly outnumbered the other. In other arrays, one color slightly outnumbered the other.
Test-takers of the same age showed large differences in how accurately they could assess the dots, with the highest average scores coming around age 30, the researchers report. Teens and adults with a robust number sense reported doing moderately better at math in school and on the math portion of the SAT than those with a weak number sense.
Everyday activities, such as quickly deciding which of several supermarket check-out lines is shortest, may strengthen a person?s number sense, Halberda says. His team is devising an action video game containing number-related decisions that will aim to boost children?s number sense precision.
?Training to make numerosity discriminations could improve mathematics learning, whether it turns out that the ability to estimate quantities is the foundation for learning about numbers or just improves math confidence,? says cognitive neuropsychologist Brian Butterworth of University College London.?
Previous research had linked a keen number sense to superior math achievement in elementary school (SN: 9/27/08, p. 10).
Number sense is one of many influences on math performance in school and throughout life, Halberda says. A long-term study of U.S. and British youngsters published online June 14 in Psychological Science finds, for instance, that students who grasp fractions and division in grade school do particularly well in all forms of high school math.
VATICAN CITY?? The Vatican has brought in the Fox News correspondent in Rome to help improve its communications strategy as it tries to cope with years of communications blunders and one of its most serious scandals in decades, The Associated Press learned Saturday.
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Greg Burke, 52, will leave Fox to become a senior communications adviser in the Vatican's secretariat of state, the Vatican and Burke told the AP.
"I'm a bit nervous but very excited. Let's just say it's a challenge," Burke said in a phone interview.
He defined his job, which he said he had been offered twice before, as: "You're shaping the message, you're molding the message, and you're trying to make sure everyone remains on-message. And that's tough."
The Vatican spokesman, the Rev. Federico Lombardi, confirmed the move to the AP, saying Burke will help integrate communications issues within the Vatican's top administrative office, the secretariat of state, and will help handle its relations with the Holy See press office and other Vatican communications offices.
Burke, a native of St. Louis, Missouri, is a member of the conservative Opus Dei movement. Pope John Paul II's longtime spokesman, Joaquin Navarro-Valls, was also a member of Opus Dei.
The Vatican has been bedeviled by communications blunders ever since Pope Benedict XVI's 2005 election, and is currently dealing with a scandal over Vatican documents that were leaked to Italian journalists. While the scandal is serious ? Benedict himself convened a special meeting of cardinals Saturday to try to cope with it ? the Vatican's communications problems long predate it.
Benedict's now-infamous speech about Muslims and violence, his 2009 decision to rehabilitate a schismatic bishop who denied the Holocaust, and the Vatican's response to the 2010 explosion of the sex abuse scandal are just a few of the blunders that have tarnished Benedict's papacy.
Even the Vatican's response to the leaks from within the Vatican of sensitive papal documents hasn't involved a terribly sophisticated public relations strategy. Just last week the Vatican No. 2, Cardinal Tarcisio Bertone, blamed the media and the devil for fueling the scandal and accused journalists of "pretending to be Dan Brown."
Brown wrote "The Da Vinci Code," the best-selling fictional account that portrayed Opus Dei ? of which Bertone's new communications adviser is a member ? as being at the root of an international Catholic conspiracy.
Burke acknowledged the task ahead but said that after turning down the Vatican twice before, he went with his gut and accepted the third time around. "This is an opportunity and challenge that I'm not going to get again," he said.
He said he didn't know what, if any, role his membership in Opus Dei played. Opus is greatly in favor in the Vatican these days, particularly as other new religious movements such as the Legion of Christ have lost credibility with their own problems. Currently, for example, the cardinal who is heading the Vatican's internal investigation into the leaks of documents is the Opus Dei prelate, Cardinal Julian Herranz.
"I'm an old-fashioned Midwestern Catholic whose mother went to Mass every day," Burke said. "Am I being hired because I'm in Opus Dei?" he asked. "It might come into play." But he noted he was also in Opus when he was hired by Time and Fox.
Burke has been a Fox correspondent since he joined the conservative U.S. network in 2001. He was the Time magazine correspondent in Rome for a decade before that. At Fox, he led the network's coverage of the death of John Paul and election of Benedict, and has covered the papacy since then, traveling with the pope around the globe. But he has also used Rome as a base for non-Vatican reporting, including several stints in the Middle East during the last intifada, labor law protests in France and the terrorist attacks in London and Madrid.
He is a graduate of Columbia University's School of Journalism.
Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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Public release date: 29-Jun-2012
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